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R-IMPP

Names

[ CAS No. ]:
2133832-83-2

[ Name ]:
R-IMPP

Biological Activity

[Description]:

R-IMPP is an inhibitor of PCSK9 secretion.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer
Research Areas >> Cardiovascular Disease

[In Vitro]

R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].

[References]

[1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C24H27N3O2

[ Molecular Weight ]:
389.49

[ Storage condition ]:
-20℃

Related Compounds

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