Lycobetaine(Ungeremine)

Modify Date: 2025-08-21 09:57:42

Lycobetaine(Ungeremine) structure	Common Name	Lycobetaine(Ungeremine)
	CAS Number	2121-12-2	Molecular Weight	266.27100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₂NO₃	Melting Point	270-272ºC (dec.)
	MSDS	N/A	Flash Point	N/A

Use of Lycobetaine(Ungeremine)

Ungeremine, a phenanthridine type alkaloid, is extracted of the bulbs of Pancratium Illyricum. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Ungeremine displays cytotoxic activity towards the 9 cancer cell lines, including drug-sensitive and MDR phenotypes. Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1][2].

Name	ungeremine
Synonym	More Synonyms

Description	Ungeremine, a phenanthridine type alkaloid, is extracted of the bulbs of Pancratium Illyricum. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Ungeremine displays cytotoxic activity towards the 9 cancer cell lines, including drug-sensitive and MDR phenotypes. Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Casu L, et al. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. [2]. Mbaveng A, et al. Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine. 2019 Jul;60:152832.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Signaling Pathways >> Apoptosis >> Ferroptosis

Signaling Pathways >> Apoptosis >> Caspase

Signaling Pathways >> Autophagy >> Autophagy

References

[1]. Casu L, et al. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.

[2]. Mbaveng A, et al. Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine. 2019 Jul;60:152832.

Melting Point	270-272ºC (dec.)
Molecular Formula	C₁₆H₁₂NO₃
Molecular Weight	266.27100
Exact Mass	266.08200
PSA	42.57000
LogP	2.27090

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2827500

CHEMICAL NAME :: Lycoranium, 1,2,3,3a,6,7,12b,12c-octadehydro-2-hydroxy-

CAS REGISTRY NUMBER :: 2121-12-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H12-N-O3

MOLECULAR WEIGHT :: 266.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,316,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,316,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 75 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 54,114,1988

Ungerimine

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