DK419

Modify Date: 2025-09-23 11:39:20

DK419 Structure
DK419 structure
 Common Name DK419
CAS Number 2102672-22-8 Molecular Weight 407.70
Density N/A Boiling Point N/A
Molecular Formula C16H8ClF6N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DK419


DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].

 Names

Name DK419

 DK419 Biological Activity

Description DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].
Related Catalog
Target

Wnt/β-catenin[1]

References

[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

 Chemical & Physical Properties

Molecular Formula C16H8ClF6N3O
Molecular Weight 407.70
InChIKey MWNNIGRGNSXNEA-UHFFFAOYSA-N
SMILES O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(Cl)cc2[nH]c(C(F)(F)F)nc12
Storage condition 2-8°C
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Chemsrc provides DK419(CAS#:2102672-22-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DK419 are included as well.>> amp version: DK419

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