DK419

Names

[ Name ]:
DK419

Biological Activity

[Description]:

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

Wnt/β-catenin[1]

[References]

[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₈ClF₆N₃O

[ Molecular Weight ]:
407.70

[ Storage condition ]:
2-8°C