2102672-22-8

2102672-22-8 structure

Name: DK419
Chemical Name: DK419
CAS Number: 2102672-22-8
Molecular Formula: C₁₆H₈ClF₆N₃O
Molecular Weight: 407.70
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2019-06-30 22:42:15
Modify Date: 2024-01-22 16:31:48
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].

Name	DK419

Description	DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	Wnt/β-catenin[1]
References	[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.