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2102672-22-8

2102672-22-8 structure
2102672-22-8 structure
  • Name: DK419
  • Chemical Name: DK419
  • CAS Number: 2102672-22-8
  • Molecular Formula: C16H8ClF6N3O
  • Molecular Weight: 407.70
  • Catalog: Signaling Pathways Stem Cell/Wnt Wnt
  • Create Date: 2019-06-30 22:42:15
  • Modify Date: 2024-01-22 16:31:48
  • DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].

Name DK419
Description DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].
Related Catalog
Target

Wnt/β-catenin[1]

References

[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

Molecular Formula C16H8ClF6N3O
Molecular Weight 407.70
Storage condition 2-8°C
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