BLU-667 trans form structure
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Common Name | BLU-667 trans form | ||
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CAS Number | 2097132-93-7 | Molecular Weight | 533.60 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C27H32FN9O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of BLU-667 trans formcis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2]. |
Name | cis-Pralsetinib |
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Description | cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2]. |
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Related Catalog | |
Target |
IC50: 0.4 nM (WT RET), 0.3 nM (RET V804L), 0.4 nM (RET V804M), 0.4 nM (RET M918T), 0.4 nM (CCDC6-RET)[2] |
References |
[1]. http://www.blueprintmedicines.com/wp-content/uploads/2017/10/BLU-667-EORTC-2017-BPM.pdf |
Molecular Formula | C27H32FN9O2 |
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Molecular Weight | 533.60 |