2097132-93-7
2097132-93-7 structure
- Name: BLU-667 trans form
- Chemical Name: cis-Pralsetinib
- CAS Number: 2097132-93-7
- Molecular Formula: C27H32FN9O2
- Molecular Weight: 533.60
- Catalog: Research Areas Cancer
- Create Date: 2019-08-03 23:22:59
- Modify Date: 2024-01-05 23:13:11
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cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2].
| Name | cis-Pralsetinib |
|---|
| Description | cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.4 nM (WT RET), 0.3 nM (RET V804L), 0.4 nM (RET V804M), 0.4 nM (RET M918T), 0.4 nM (CCDC6-RET)[2] |
| References |
[1]. http://www.blueprintmedicines.com/wp-content/uploads/2017/10/BLU-667-EORTC-2017-BPM.pdf |
| Molecular Formula | C27H32FN9O2 |
|---|---|
| Molecular Weight | 533.60 |