RET-IN-23c
Modify Date: 2024-09-16 16:41:37
RET-IN-23c structure
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Common Name | RET-IN-23c | ||
|---|---|---|---|---|
| CAS Number | 2095172-11-3 | Molecular Weight | 288.311 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H16N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RET-IN-23cRET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM. |
| Name | RET-IN-23c |
|---|
| Description | RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM. |
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| References | References 1. Wang C, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548. View Related Products by Target RET Tyrosine Kinase (c-RET) |
| Molecular Formula | C13H16N6O2 |
|---|---|
| Molecular Weight | 288.311 |