RET-IN-23c

Names

[ CAS No. ]:
2095172-11-3

[ Name ]:
RET-IN-23c

Biological Activity

[Description]:

RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM.

[References]

References 1. Wang C, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548. View Related Products by Target RET Tyrosine Kinase (c-RET)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₆N₆O₂

[ Molecular Weight ]:
288.311

Related Compounds

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