Dichloro-all-trans-retinone

Modify Date: 2024-04-06 01:29:14

Dichloro-all-trans-retinone Structure
Dichloro-all-trans-retinone structure
 Common Name Dichloro-all-trans-retinone
CAS Number 2089135-65-7 Molecular Weight 367.354
Density N/A Boiling Point N/A
Molecular Formula C21H28Cl2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Dichloro-all-trans-retinone


Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde.

 Names

Name Dichloro-all-trans-retinone

 Dichloro-all-trans-retinone Biological Activity

Description Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde.
References 1. Angelica R Harper, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5766-5779.

 Chemical & Physical Properties

Molecular Formula C21H28Cl2O
Molecular Weight 367.354
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