Dichloro-all-trans-retinone
Names
[ CAS No. ]:
2089135-65-7
[ Name ]:
Dichloro-all-trans-retinone
Biological Activity
[Description]:
Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde.
[References]
1. Angelica R Harper, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5766-5779.
Chemical & Physical Properties
[ Molecular Formula ]:
C21H28Cl2O
[ Molecular Weight ]:
367.354
Related Compounds
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