2089135-65-7
2089135-65-7 structure
- Name: Dichloro-all-trans-retinone
- Chemical Name: Dichloro-all-trans-retinone
- CAS Number: 2089135-65-7
- Molecular Formula: C21H28Cl2O
- Molecular Weight: 367.354
- Create Date: 2022-07-15 18:54:50
- Modify Date: 2024-04-06 01:29:14
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Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde.
| Name | Dichloro-all-trans-retinone |
|---|
| Description | Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde. |
|---|---|
| References | 1. Angelica R Harper, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5766-5779. |
| Molecular Formula | C21H28Cl2O |
|---|---|
| Molecular Weight | 367.354 |