ASP2397

Modify Date: 2024-01-09 10:33:21

ASP2397 Structure
ASP2397 structure
Common Name ASP2397
CAS Number 2088622-19-7 Molecular Weight 914.94
Density N/A Boiling Point N/A
Molecular Formula C40H59AlN10O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ASP2397


ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].

 Names

Name ASP2397

 ASP2397 Biological Activity

Description ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].
Related Catalog
Target

MIC: 1-4 μg/mL (Aspergillus species)[1].

In Vivo ASP2397 (1, 2, 4, or 8 mg/kg, s.c., b.i.d.) significantly improves survival in IPA models in mice[1]. Animal Model: A mouse model of A. fumigatus-induced IPA[1]. Dosage: 1, 2, 4, 8 mg/kg. Administration: S.C., BID, from day 1 for 3 days. Result: Significantly improved survival.
References

[1]. Nakamura I, et al. ASP2397, a novel natural compound that exhibits rapid and potent fungicidal activity against Aspergillus species through a specific transporter. Antimicrob Agents Chemother. 2019 Aug 12. pii: AAC.02689-18.

 Chemical & Physical Properties

Molecular Formula C40H59AlN10O13
Molecular Weight 914.94
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