2088622-19-7

2088622-19-7 structure

Name: ASP2397
Chemical Name: ASP2397
CAS Number: 2088622-19-7
Molecular Formula: C₄₀H₅₉AlN₁₀O₁₃
Molecular Weight: 914.94
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2019-10-08 10:38:52
Modify Date: 2024-01-09 10:33:21
ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].

Name	ASP2397

Description	ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
Target	MIC: 1-4 μg/mL (Aspergillus species)[1].
In Vivo	ASP2397 (1, 2, 4, or 8 mg/kg, s.c., b.i.d.) significantly improves survival in IPA models in mice[1]. Animal Model: A mouse model of A. fumigatus-induced IPA[1]. Dosage: 1, 2, 4, 8 mg/kg. Administration: S.C., BID, from day 1 for 3 days. Result: Significantly improved survival.
References	[1]. Nakamura I, et al. ASP2397, a novel natural compound that exhibits rapid and potent fungicidal activity against Aspergillus species through a specific transporter. Antimicrob Agents Chemother. 2019 Aug 12. pii: AAC.02689-18.

Molecular Formula	C₄₀H₅₉AlN₁₀O₁₃
Molecular Weight	914.94