ASP2397

Names

[ CAS No. ]:
2088622-19-7

[ Name ]:
ASP2397

Biological Activity

[Description]:

ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[Target]

MIC: 1-4 μg/mL (Aspergillus species)[1].

[In Vivo]

ASP2397 (1, 2, 4, or 8 mg/kg, s.c., b.i.d.) significantly improves survival in IPA models in mice[1]. Animal Model: A mouse model of A. fumigatus-induced IPA[1]. Dosage: 1, 2, 4, 8 mg/kg. Administration: S.C., BID, from day 1 for 3 days. Result: Significantly improved survival.

[References]

[1]. Nakamura I, et al. ASP2397, a novel natural compound that exhibits rapid and potent fungicidal activity against Aspergillus species through a specific transporter. Antimicrob Agents Chemother. 2019 Aug 12. pii: AAC.02689-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₅₉AlN₁₀O₁₃

[ Molecular Weight ]:
914.94

Related Compounds

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