VBIT-4
Modify Date: 2025-08-26 14:27:41
VBIT-4 structure
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Common Name | VBIT-4 | ||
|---|---|---|---|---|
| CAS Number | 2086257-77-2 | Molecular Weight | 457.87 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23ClF3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VBIT-4VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. |
| Name | VBIT-4 |
|---|
| Description | VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. |
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| Related Catalog | |
| Target |
Kd: 17 μM (VDAC1)[1] Apoptosis[1] |
| In Vitro | VBIT-4 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively[1]. Apoptosis Analysis[1] Cell Line: HEK-293 cells Concentration: 0.1, 1, and 10 μM Incubation Time: Result: Inhibited apoptosis with an IC50 of 2.9±0.12 μM. |
| References |
| Molecular Formula | C21H23ClF3N3O3 |
|---|---|
| Molecular Weight | 457.87 |
| InChIKey | QYSQXVAEFPWMEM-UHFFFAOYSA-N |
| SMILES | O=C(CC(CO)N1CCN(c2ccc(OC(F)(F)F)cc2)CC1)Nc1ccc(Cl)cc1 |
| Storage condition | -20°C |