Name | VBIT-4 |
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Description | VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. |
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Related Catalog | |
Target |
Kd: 17 μM (VDAC1)[1] Apoptosis[1] |
In Vitro | VBIT-4 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively[1]. Apoptosis Analysis[1] Cell Line: HEK-293 cells Concentration: 0.1, 1, and 10 μM Incubation Time: Result: Inhibited apoptosis with an IC50 of 2.9±0.12 μM. |
References |
Molecular Formula | C21H23ClF3N3O3 |
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Molecular Weight | 457.87 |
Storage condition | -20°C |