2086257-77-2

2086257-77-2 structure

Name: VBIT-4
Chemical Name: VBIT-4
CAS Number: 2086257-77-2
Molecular Formula: C₂₁H₂₃ClF₃N₃O₃
Molecular Weight: 457.87
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-01-23 13:31:51
Modify Date: 2024-01-04 19:38:03
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

Name	VBIT-4

Description	VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
Target	Kd: 17 μM (VDAC1)[1] Apoptosis[1]
In Vitro	VBIT-4 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively[1]. Apoptosis Analysis[1] Cell Line: HEK-293 cells Concentration: 0.1, 1, and 10 μM Incubation Time: Result: Inhibited apoptosis with an IC50 of 2.9±0.12 μM.
References	[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.