JHU395

Modify Date: 2025-08-27 17:47:48

JHU395 Structure
JHU395 structure
Common Name JHU395
CAS Number 2079938-92-2 Molecular Weight 447.48
Density N/A Boiling Point N/A
Molecular Formula C22H29N3O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JHU395


JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1].

 Names

Name JHU395

 JHU395 Biological Activity

Description JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1].
Related Catalog
References

[1]. Lemberg KM, et al. The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheralnerve sheath tumor. Mol Cancer Ther. 2019 Oct 8. pii: molcanther.0319.2019.

 Chemical & Physical Properties

Molecular Formula C22H29N3O7
Molecular Weight 447.48
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.