JHU395

Names

[ CAS No. ]:
2079938-92-2

[ Name ]:
JHU395

Biological Activity

[Description]:

JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Lemberg KM, et al. The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheralnerve sheath tumor. Mol Cancer Ther. 2019 Oct 8. pii: molcanther.0319.2019.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₉N₃O₇

[ Molecular Weight ]:
447.48

Related Compounds

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