2079938-92-2

2079938-92-2 structure

Name: JHU395
Chemical Name: JHU395
CAS Number: 2079938-92-2
Molecular Formula: C₂₂H₂₉N₃O₇
Molecular Weight: 447.48
Catalog: Research Areas Cancer
Create Date: 2019-12-08 12:27:32
Modify Date: 2025-08-27 17:47:48
JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1].

Name	JHU395

Description	JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Lemberg KM, et al. The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheralnerve sheath tumor. Mol Cancer Ther. 2019 Oct 8. pii: molcanther.0319.2019.

Molecular Formula	C₂₂H₂₉N₃O₇
Molecular Weight	447.48