Hydroxy-PEG5-acid

Modify Date: 2024-01-05 23:00:41

Hydroxy-PEG5-acid Structure
Hydroxy-PEG5-acid structure
Common Name Hydroxy-PEG5-acid
CAS Number 2079768-50-4 Molecular Weight 310.341
Density 1.2±0.1 g/cm3 Boiling Point 455.7±45.0 °C at 760 mmHg
Molecular Formula C13H26O8 Melting Point N/A
MSDS N/A Flash Point 162.3±22.2 °C

 Use of Hydroxy-PEG5-acid


Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
Synonym More Synonyms

 Hydroxy-PEG5-acid Biological Activity

Description Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 455.7±45.0 °C at 760 mmHg
Molecular Formula C13H26O8
Molecular Weight 310.341
Flash Point 162.3±22.2 °C
Exact Mass 310.162781
LogP -2.42
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.467

 Synonyms

1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
MFCD31380407
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-hydroxy-