Benzenecarboximidamide hydrochloride hydrate

Modify Date: 2024-01-04 18:36:47

Benzenecarboximidamide hydrochloride hydrate Structure
Benzenecarboximidamide hydrochloride hydrate structure
Common Name Benzenecarboximidamide hydrochloride hydrate
CAS Number 206752-36-5 Molecular Weight 174.628
Density N/A Boiling Point 208.5ºC at 760mmHg
Molecular Formula C7H8N2.ClH.xH2O Melting Point 86-88 °C(lit.)
MSDS USA Flash Point 79.9ºC

 Use of Benzenecarboximidamide hydrochloride hydrate


Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2].

 Names

Name benzenecarboximidamide,hydrate,hydrochloride
Synonym More Synonyms

  Biological Activity

Description Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2].
Related Catalog
Target

Ki: 20 μM (Tryptase), 21 μM (Trypsin), 97 μM (uPA), 110 μM (Factor Xa), 320 μM (Thrombin), 750 μM (tPA)[1]

References

[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.  

[2]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.  

 Chemical & Physical Properties

Boiling Point 208.5ºC at 760mmHg
Melting Point 86-88 °C(lit.)
Molecular Formula C7H8N2.ClH.xH2O
Molecular Weight 174.628
Flash Point 79.9ºC
Exact Mass 174.055984
PSA 59.10000
LogP 2.50840
Vapour Pressure 0.213mmHg at 25°C
Storage condition 0-6°C
Water Solubility soluble

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CV6260000

 Articles6

More Articles
Preparation of extracts from yeast.

Meth. Enzymol. 182 , 154, (1990)

Thermodynamics of the interaction between oxytocin and its myometrial receptor in sheep: a stepwise binding mechanism.

Biochem. Pharmacol. 91(1) , 119-27, (2014)

Entropy (ΔS), enthalpy (ΔH) and heat capacity (ΔCp) changes attending the oxytocin interaction with its two binding sites on myometrial cell membranes in sheep were derived from the temperature depend...

Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface.

Biomaterials 73 , 42-50, (2015)

The lubricating proteoglycan, lubricin, facilitates the remarkable low friction and wear properties of articular cartilage in the synovial joints of the body. Lubricin lines the joint surfaces and pla...

 Synonyms

EINECS 216-795-4
Benzenecarboximidamide hydrochloride hydrate
Benzamidine HCl Hydrate
MFCD00066285
Benzenecarboximidamide, hydrochloride, hydrate (1:1:1)
AMIDINOBENZENE HYDROCHLORIDE
Benzamidine hydrochloride, hydrate
Benzamidine hydrochloride hydrate
Benzamidine Hydrochloride Monohydrate
Benzamidinium chloride
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Benzenecarboximidamide hydrochloride hydrate suppliers


Price: ¥150/5 g

Reference only. check more Benzenecarboximidamide hydrochloride hydrate price