Brd9185

Modify Date: 2025-09-15 21:42:13

Brd9185 Structure
Brd9185 structure
Common Name Brd9185
CAS Number 2057420-29-6 Molecular Weight 485.42
Density N/A Boiling Point N/A
Molecular Formula C23H21F6N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Brd9185


BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].

 Names

Name BRD9185

 Brd9185 Biological Activity

Description BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].
Related Catalog
Target

EC50: 16 nM (DHODH in vitro)[1].

References

[1]. Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8(4):438-442.

 Chemical & Physical Properties

Molecular Formula C23H21F6N3O2
Molecular Weight 485.42
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