Brd9185

Names

[ CAS No. ]:
2057420-29-6

[ Name ]:
Brd9185

Biological Activity

[Description]:

BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

[Target]

EC50: 16 nM (DHODH in vitro)[1].

[References]

[1]. Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8(4):438-442.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁F₆N₃O₂

[ Molecular Weight ]:
485.42

Related Compounds

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