RTI 4229-336

Modify Date: 2025-08-27 07:31:34

RTI 4229-336 Structure
RTI 4229-336 structure
Common Name RTI 4229-336
CAS Number 204069-50-1 Molecular Weight 429.38
Density N/A Boiling Point N/A
Molecular Formula C24H26Cl2N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RTI 4229-336


RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].

 Names

Name RTI-336
Synonym More Synonyms

 RTI 4229-336 Biological Activity

Description RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].
Related Catalog
In Vivo RTI 336(3 mg/kg;皮下注射;30 分钟预处理)显著减少 Lewis 大鼠对成瘾剂的输注次数[1]。 RTI 336(3 毫克/千克;腹腔注射;30 分钟预处理)降低 Lewis 大鼠中由成瘾剂诱导的反应率(杠杆按压/秒)[1]。
References

[1]. Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055(1-2):186-95.  

 Chemical & Physical Properties

Molecular Formula C24H26Cl2N2O
Molecular Weight 429.38
Exact Mass 428.142212

 Synonyms

(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-1,2-oxazol-5-yl]-8-azabicyclo[3.2.1]octane hydrochloride (1:1)
8-Azabicyclo[3.2.1]octane, 3-(4-chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-5-isoxazolyl]-, (1R,2S,3S,5S)-, hydrochloride (1:1)
RTI-336
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