Allopregnanolone-d4

Modify Date: 2024-01-03 09:48:59

Allopregnanolone-d4 Structure
Allopregnanolone-d4 structure
Common Name Allopregnanolone-d4
CAS Number 203805-85-0 Molecular Weight 322.518
Density 1.1±0.1 g/cm3 Boiling Point 431.2±18.0 °C at 760 mmHg
Molecular Formula C21H30D4O2 Melting Point N/A
MSDS N/A Flash Point 183.9±13.8 °C

 Use of Allopregnanolone-d4


Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain[1].

 Names

Name (3α,5α,8α)-3-Hydroxy(1,2,2,3-2H4)pregnan-20-one
Synonym More Synonyms

 Allopregnanolone-d4 Biological Activity

Description Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Dornellas APS, et al. Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage. Front Pharmacol. 2021;11:608887. Published 2021 Jan 14.

[3]. Kimball A, et al. The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause. Psychoneuroendocrinology. 2020;112:104512.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 431.2±18.0 °C at 760 mmHg
Molecular Formula C21H30D4O2
Molecular Weight 322.518
Flash Point 183.9±13.8 °C
Exact Mass 322.280975
LogP 4.89
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.524

 Synonyms

(3α,5α,8α)-3-Hydroxy(1,2,2,3-H)pregnan-20-one
Pregnan-20-one-1,2,2,3-d, 3-hydroxy-, (3α,5α,8α)-