Nortriptyline-d3 hydrochloride

Modify Date: 2024-01-13 18:12:34

Nortriptyline-d3 hydrochloride Structure
Nortriptyline-d3 hydrochloride structure
Common Name Nortriptyline-d3 hydrochloride
CAS Number 203784-52-5 Molecular Weight 302.856
Density N/A Boiling Point N/A
Molecular Formula C19H19ClD3N Melting Point 213-215ºC
MSDS N/A Flash Point N/A

 Use of Nortriptyline-d3 hydrochloride


Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].

 Names

Name 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N-(trideuteriomethyl)propan-1-amine,hydrochloride
Synonym More Synonyms

 Nortriptyline-d3 hydrochloride Biological Activity

Description Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

 Chemical & Physical Properties

Melting Point 213-215ºC
Molecular Formula C19H19ClD3N
Molecular Weight 302.856
Exact Mass 302.162903
PSA 12.03000
LogP 5.01930

 Synonyms

Nortrilen-d3
Pamelor-d3
Norzepine-d3
Nortriptyline-d3 Hydrochloride
Allegron-d3
3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(H)methyl-1-propanamine hydrochloride (1:1)
Acetexa-d3
Sensival-d3
3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(H)methylpropan-1-amine hydrochloride (1:1)
Vividyl-d3
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-(methyl-d)-, hydrochloride (1:1)