347840-07-7

347840-07-7 structure

Name: Doxepin D3 Hydrochloride
Chemical Name: Doxepin-D3 hydrochloride
CAS Number: 347840-07-7
Molecular Formula: C₁₉H₁₉D₃ClNO
Molecular Weight: 318.856
Catalog: analytical chemistry Standard standard material
Create Date: 2018-08-23 01:01:27
Modify Date: 2024-01-02 17:31:56
Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant used as a sedative. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

Name	Doxepin-D3 hydrochloride
Synonyms	1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N-methyl-N-(methyl-d)-, hydrochloride (1:1) 3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methyl-N-(H)methyl-1-propanamine hydrochloride (1:1) 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methyl-N-(trideuteriomethyl)propan-1-amine,hydrochloride Doxepin-d3Hydrochloride

Description	Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant used as a sedative. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Histamine receptor H1; CYP450 2C19 and CYP450 1A2[2]
References	[1]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63. [2]. Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.

Boiling Point	64.0-65.0 °C at 760 mmHg
Melting Point	162-164ºC
Molecular Formula	C₁₉H₁₉D₃ClNO
Molecular Weight	318.856
Flash Point	9℃
Exact Mass	318.157837
PSA	12.47000
LogP	4.76440
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Stability	Store in Freezer at -20°C

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution