AHN 1-055 hydrochloride
Modify Date: 2024-01-12 12:54:11
AHN 1-055 hydrochloride structure
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Common Name | AHN 1-055 hydrochloride | ||
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| CAS Number | 202646-03-5 | Molecular Weight | 379.871 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H24ClF2NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AHN 1-055 hydrochlorideAHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse[1]. |
| Name | 3-[Bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse[1]. |
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| Related Catalog | |
| Target |
IC50: 71 nM (dopamine uptake)[1] |
| In Vivo | AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC50 of 311.8 ng/ml in vivo[1]. AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1]. Animal Model: Adult male Sprague Dawley rats (250-275 g)[1] Dosage: 5 mg/kg (Pharmacokinetic Analysis) Administration: I.v. administration Result: Cmax (1.48 mg/L); T1/2 (7.69 h). |
| References |
| Molecular Formula | C21H24ClF2NO |
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| Molecular Weight | 379.871 |
| Exact Mass | 379.151459 |
| 8-Azabicyclo[3.2.1]octane, 3-[bis(4-fluorophenyl)methoxy]-8-methyl-, hydrochloride (1:1) |
| 3-[Bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride (1:1) |