Ginkgolic acid C13:0 structure
|
Common Name | Ginkgolic acid C13:0 | ||
|---|---|---|---|---|
| CAS Number | 20261-38-5 | Molecular Weight | 320.466 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 449.5±33.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 239.8±21.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Ginkgolic acid C13:0Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity.IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL).Target:In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo: |
| Name | 2-hydroxy-6-tridecylbenzoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity.IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL).Target:In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo: |
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| Related Catalog | |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 449.5±33.0 °C at 760 mmHg |
| Molecular Formula | C20H32O3 |
| Molecular Weight | 320.466 |
| Flash Point | 239.8±21.9 °C |
| Exact Mass | 320.235138 |
| PSA | 57.53000 |
| LogP | 8.90 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.519 |
| InChIKey | VEPUCZUJLKAVNM-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCc1cccc(O)c1C(=O)O |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 29163990 |
|
~95%
Ginkgolic acid C13:0 CAS#:20261-38-5 |
| Literature: Liebigs Annalen, , # 12 p. 2209 - 2220 |
|
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Ginkgolic acid C13:0 CAS#:20261-38-5 |
| Literature: Liebigs Annalen, , # 12 p. 2209 - 2220 |
|
~%
Ginkgolic acid C13:0 CAS#:20261-38-5 |
| Literature: Liebigs Annalen, , # 12 p. 2209 - 2220 |
|
~%
Ginkgolic acid C13:0 CAS#:20261-38-5 |
| Literature: Liebigs Annalen, , # 12 p. 2209 - 2220 |
|
~%
Ginkgolic acid C13:0 CAS#:20261-38-5 |
| Literature: Liebigs Annalen, , # 12 p. 2209 - 2220 |
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The anti-inflammatory activity of marine natural products--6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate.
Agents Actions 10(4) , 361-7, (1980) Three novel marine substances, 6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate, isolated from a brown alga, a soft coral and a dictyoceratid sponge respectively, were active af... |
| Benzoic acid,2-hydroxy-6-tridecyl |
| 6-n-Tridecylsalicylic acid |
| Benzoic acid, 2-hydroxy-6-tridecyl- |
| 6-tridecyl anacardic acid |
| 2-Hydroxy-6-tridecylbenzoic acid,6-Tridecylsalicylic acid,Ginkgoneolic acid |
| Ginkgoneolic acid |
| 6-tridecylsalicylic acid |
| 2-Hydroxy-6-tridecylbenzoic acid |
| Ginkgolic Acid |
| 6-tridecyl phenol |
| Ginkgolic acid C13:0 |
| Ginkgolic Acid (C13:0) |