CGP 3466B maleate

Modify Date: 2024-01-03 02:57:30

CGP 3466B maleate structure	Common Name	CGP 3466B maleate
	CAS Number	200189-97-5	Molecular Weight	391.41700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₁NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CGP 3466B maleate

Omigapil maleate (CGP3446B maleate) is an orally bioavailable apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD)[1]. Omigapil maleate, a GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that Omigapil maleate has the potential for the research of Alzheimer's disease[2].

Name	N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine,(Z)-but-2-enedioic acid
Synonym	More Synonyms

Description	Omigapil maleate (CGP3446B maleate) is an orally bioavailable apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD)[1]. Omigapil maleate, a GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that Omigapil maleate has the potential for the research of Alzheimer's disease[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	Apoptosis[2]
In Vivo	Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force[1]. Animal Model: 12-week-old dyW/ mag mice[1] Dosage: 0.1 mg/kg Administration: For the first week of drug treatment, administered once daily by intraperitoneal injection. After weaning (3 weeks of age), applied once daily by oral gavage. Result: Reduced the muscle fibre loss. Many of the functional parameters were significantly improved by omigapil.
References	[1]. Sarina Meinen, et al. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Mol Med. 2011 Aug;3(8):465-79. [2]. Tanusree Sen, et al. Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β. Sci Signal. 2018 Mar 20;11(522):eaao6765.

Molecular Formula	C₂₃H₂₁NO₅
Molecular Weight	391.41700
Exact Mass	391.14200
PSA	87.07000
LogP	3.60970

JHW 007 hydrochloride

Omigapil maleate

Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine maleate

TCH-346

CGP 3466B

UNII-3Q69BFZ4OP

N-(Dibenz(b,f)oxepin-10-ylmethyl)-N-methyl-N-(2-propynyl)amine monomaleic acid salt

DC Chemicals Limited
China
Product Name: CGP 3466B
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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