JHU-083

Modify Date: 2024-01-02 17:17:58

JHU-083 Structure
JHU-083 structure
 Common Name JHU-083
CAS Number 1998725-11-3 Molecular Weight 312.36
Density N/A Boiling Point N/A
Molecular Formula C14H24N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JHU-083


JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2].

 Names

Name JHU-083

 JHU-083 Biological Activity

Description JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2].
Related Catalog
Target

Glutamine[2]

References

[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694.

[2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.

 Chemical & Physical Properties

Molecular Formula C14H24N4O4
Molecular Weight 312.36
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Chemsrc provides JHU-083(CAS#:1998725-11-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of JHU-083 are included as well.>> amp version: JHU-083

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