PhiKan 083
Modify Date: 2024-01-02 12:46:38
PhiKan 083 structure
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Common Name | PhiKan 083 | ||
|---|---|---|---|---|
| CAS Number | 1050480-30-2 | Molecular Weight | 274.789 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H19ClN2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PhiKan 083PhiKan 083 hydrochloride is a carbazole derivative, which can stabilize Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR, used for cancer research. |
| Name | PhiKan 083 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | PhiKan 083 hydrochloride is a carbazole derivative, which can stabilize Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR, used for cancer research. |
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| Related Catalog | |
| Target |
Kd: 167 μM (T-p53C-Y220C)[1] |
| In Vitro | PhiKan 083 hydrochloride is a stabilizer of Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR. Analytical ultracentrifugation gives a Kd of 170 μM for PhiKan083, at 10°C. Isothermal titration of PhiKan083 with T-p53C-Y220C gives 1:1 stoichiometry and a Kd of 125 ± 10 μM[1]. PhiKan083 can binds with the cavity on the surface of Y220C-mutated p53[2]. |
| References |
| Molecular Formula | C16H19ClN2 |
|---|---|
| Molecular Weight | 274.789 |
| Exact Mass | 274.123688 |
| Storage condition | 2-8℃ |
| MFCD07168924 |
| 9H-Carbazole-3-methanamine, 9-ethyl-N-methyl-, hydrochloride (1:1) |
| 1-(9-Ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride (1:1) |