Kolavenol

Modify Date: 2024-01-08 15:41:35

Kolavenol Structure
Kolavenol structure
Common Name Kolavenol
CAS Number 19941-83-4 Molecular Weight 290.48
Density 0.9±0.1 g/cm3 Boiling Point 377.7±11.0 °C at 760 mmHg
Molecular Formula C20H34O Melting Point N/A
MSDS N/A Flash Point 123.4±15.6 °C

 Use of Kolavenol


Kolavenol can be isolated from the root of Solidago altissima L. Kolavenol enantiomer has trypanocidal activity against Trypanosoma brucei rhodesiense, the causative agent of the acute form of human African trypanosomiasis, with an IC50 of 2.5 μg/ml (8.6 μM)[1][2].

 Names

Name Kolavenol
Synonym More Synonyms

 Kolavenol Biological Activity

Description Kolavenol can be isolated from the root of Solidago altissima L. Kolavenol enantiomer has trypanocidal activity against Trypanosoma brucei rhodesiense, the causative agent of the acute form of human African trypanosomiasis, with an IC50 of 2.5 μg/ml (8.6 μM)[1][2].
Related Catalog
References

[1]. Kusumoto S, et al. The Structure and the Stereochemistry of Solidagonic Acid[J]. Bulletin of the Chemical Society of Japan, 1969, 42(3): 812-820.

[2]. Freiburghaus F, et al. Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense. J Ethnopharmacol. 1998 Jul;61(3):179-83.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 377.7±11.0 °C at 760 mmHg
Molecular Formula C20H34O
Molecular Weight 290.48
Flash Point 123.4±15.6 °C
Exact Mass 290.260956
PSA 20.23000
LogP 7.53
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.490

 Synonyms

(2E)-3-Methyl-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenyl]-2-penten-1-ol
(2E)-3-methyl-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-ol
2-Penten-1-ol, 3-methyl-5-[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl]-, (2E)-
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