Kolavenol

Names

[ CAS No. ]:
19941-83-4

[ Name ]:
Kolavenol

[Synonym ]:
(2E)-3-Methyl-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenyl]-2-penten-1-ol
(2E)-3-methyl-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-ol
2-Penten-1-ol, 3-methyl-5-[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl]-, (2E)-

Biological Activity

[Description]:

Kolavenol can be isolated from the root of Solidago altissima L. Kolavenol enantiomer has trypanocidal activity against Trypanosoma brucei rhodesiense, the causative agent of the acute form of human African trypanosomiasis, with an IC50 of 2.5 μg/ml (8.6 μM)[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kusumoto S, et al. The Structure and the Stereochemistry of Solidagonic Acid[J]. Bulletin of the Chemical Society of Japan, 1969, 42(3): 812-820.

[2]. Freiburghaus F, et al. Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense. J Ethnopharmacol. 1998 Jul;61(3):179-83.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
377.7±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₄O

[ Molecular Weight ]:
290.48

[ Flash Point ]:
123.4±15.6 °C

[ Exact Mass ]:
290.260956

[ PSA ]:
20.23000

[ LogP ]:
7.53

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.490

Related Compounds

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