SB 221284
Modify Date: 2024-01-05 17:15:11
SB 221284 structure
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Common Name | SB 221284 | ||
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| CAS Number | 196965-14-7 | Molecular Weight | 353.36200 | |
| Density | 1.43g/cm3 | Boiling Point | 536.2ºC at 760 mmHg | |
| Molecular Formula | C16H14F3N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 278.1ºC | |
Use of SB 221284SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1]. |
| Name | 5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
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| Synonym | More Synonyms |
| Description | SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1]. |
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| Related Catalog | |
| Target |
5-HT2A Receptor:6.4 (pKi) 5-HT2B Receptor:7.9 (pKi) 5-HT2C Receptor:8.6 (pKi) |
| In Vivo | SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1]. SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1] Animal Model: Male Sprague Dawley rats (250–360 g)[1] Dosage: 0.1~1 mg/kg Administration: I.p. Result: Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801. Animal Model: Male Sprague Dawley rats (250–360 g)[1] Dosage: 1 mg/kg Administration: I.p. Result: Significantly enhanced the magnitude and duration of the increase induced by phencyclidine. |
| References |
| Density | 1.43g/cm3 |
|---|---|
| Boiling Point | 536.2ºC at 760 mmHg |
| Molecular Formula | C16H14F3N3OS |
| Molecular Weight | 353.36200 |
| Flash Point | 278.1ºC |
| Exact Mass | 353.08100 |
| PSA | 70.53000 |
| LogP | 4.55490 |
| Vapour Pressure | 1.43E-11mmHg at 25°C |
| Index of Refraction | 1.621 |
| 5-(Methylthio)-1-(3-pyridylcarbamoyl)-6-(trifluoromethyl)indoline |
| Tocris-1379 |