AN2/AVex-73 hydrochloride salt

Modify Date: 2024-01-09 23:06:54

AN2/AVex-73 hydrochloride salt structure	Common Name	AN2/AVex-73 hydrochloride salt
	CAS Number	195615-84-0	Molecular Weight	317.853
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₄ClNO	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AN2/AVex-73 hydrochloride salt

AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.

Name	1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanamine hydrochloride (1:1)
Synonym	More Synonyms

Description	AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Research Areas >> Neurological Disease
Target	IC50: 860 nM (Sigma-1 Receptor)[1]
In Vivo	The pre-administration of AVex-73 hydrochloride (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with AVex-73 hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg[1]. The AVex-73 hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by AVex-73 hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections,AVex-73 hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The AVex-73 hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested[2].
Animal Admin	Male mice aged 7-9 weeks and weighing 32±2 g are used. Drugs (including AVex-73 hydrochloride) are brought up to each dose by dilution and injected in a volume of 100 μL/20 g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures[2].
References	[1]. Villard V, et al. Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J Psychopharmacol. 2011 Aug;25(8):1101-17. [2]. Valentine Lahmy, et al. Blockade of Tau Hyperphosphorylation and Aβ1-42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic andσ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer's Disease. Neuropsychopharmacology. 2013 Aug; 38(9): 1706-1723.

Molecular Formula	C₁₉H₂₄ClNO
Molecular Weight	317.853
Exact Mass	317.154633
Storage condition	-20℃

1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanaminhydrochlorid (1:1)

3-Furanmethanamine, tetrahydro-N,N-dimethyl-2,2-diphenyl-, hydrochloride (1:1)

1-(2,2-Diphényltétrahydro-3-furanyl)-N,N-diméthylméthanamine, chlorhydrate (1:1)

1-(2,2-Diphenyltetrahydro-3-furanyl)-N,N-dimethylmethanamine hydrochloride (1:1)

Anavex 2-73

AVex-73 hydrochloride

DC Chemicals Limited
China
Product Name: Anavex 2-73 HCl(Blarcamesine)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Anavex 2-73
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $145/10mM*1mLinDMSO

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AN2/AVex-73 hydrochloride salt

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