Metrizoic acid

Modify Date: 2024-01-17 01:55:18

Metrizoic acid Structure
Metrizoic acid structure
Common Name Metrizoic acid
CAS Number 1949-45-7 Molecular Weight 627.94000
Density 2.483g/cm3 Boiling Point 678.8ºC at 760mmHg
Molecular Formula C12H11I3N2O4 Melting Point N/A
MSDS N/A Flash Point 364.3ºC

 Use of Metrizoic acid


Metrizoic acid (Metrizoate) is an ionic contrast medium. Metrizoic acid (Metrizoate) shows high osmolality and has a risk of inducing allergic reactions[1][2][3].

 Names

Name metrizoic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 2.483g/cm3
Boiling Point 678.8ºC at 760mmHg
Molecular Formula C12H11I3N2O4
Molecular Weight 627.94000
Flash Point 364.3ºC
Exact Mass 627.78500
PSA 86.71000
LogP 3.21270
Vapour Pressure 2.35E-19mmHg at 25°C
Index of Refraction 1.77

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG0887300
CHEMICAL NAME :
Benzoic acid, 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-
CAS REGISTRY NUMBER :
1949-45-7
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C12-H11-I3-N2-O4
MOLECULAR WEIGHT :
627.95
WISWESSER LINE NOTATION :
1VN1&R BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
38100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>46800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
36 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 17,340,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
234 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

 Safety Information

Risk Phrases 36/37/38
Safety Phrases S26-S36/37/39
RTECS DG0887300
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzoic acid
Metrizoic acid
metrizoate
3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzoic Acid
3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid
Metrizoic
Metrizoesaeure
MFCD00867964
Triosil-280
5-Acetamino-3-<N-acetyl-methylamino>-2.4.6-triiod-benzoesaeure
EINECS 217-761-1