Camptothecin-20(S)-O-propionate
Modify Date: 2025-10-23 01:04:28
Camptothecin-20(S)-O-propionate structure
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Common Name | Camptothecin-20(S)-O-propionate | ||
|---|---|---|---|---|
| CAS Number | 194414-69-2 | Molecular Weight | 404.41500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H20N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Camptothecin-20(S)-O-propionateCamptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3]. |
| Name | Camptothecin-20-O-propionate |
|---|---|
| Synonym | More Synonyms |
| Description | Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3]. |
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| Related Catalog | |
| In Vivo | Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3]. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3]. Dosage: 100-1000 mg/kg/day. Administration: Oral gavage, for 2, 4 and 6 days, respectively. Result: Exhibited anti-tumor effect. |
| References |
| Molecular Formula | C23H20N2O5 |
|---|---|
| Molecular Weight | 404.41500 |
| Exact Mass | 404.13700 |
| PSA | 87.49000 |
| LogP | 3.04050 |
| Storage condition | -20°C |
| SF 6A |
| UNII-4S145C552U |
| Camptothecin-20(S)-O-propionate |
| CZ48 |