Name | Camptothecin-20-O-propionate |
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Synonyms |
SF 6A
UNII-4S145C552U Camptothecin-20(S)-O-propionate CZ48 |
Description | Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3]. |
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Related Catalog | |
In Vivo | Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3]. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3]. Dosage: 100-1000 mg/kg/day. Administration: Oral gavage, for 2, 4 and 6 days, respectively. Result: Exhibited anti-tumor effect. |
References |
Molecular Formula | C23H20N2O5 |
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Molecular Weight | 404.41500 |
Exact Mass | 404.13700 |
PSA | 87.49000 |
LogP | 3.04050 |
Storage condition | -20°C |