194414-69-2

194414-69-2 structure

Name: Camptothecin-20(S)-O-propionate
Chemical Name: Camptothecin-20-O-propionate
CAS Number: 194414-69-2
Molecular Formula: C₂₃H₂₀N₂O₅
Molecular Weight: 404.41500
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2016-02-16 22:19:57
Modify Date: 2025-10-23 01:04:28
Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].

Name	Camptothecin-20-O-propionate
Synonyms	SF 6A UNII-4S145C552U Camptothecin-20(S)-O-propionate CZ48

Description	Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
In Vivo	Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3]. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3]. Dosage: 100-1000 mg/kg/day. Administration: Oral gavage, for 2, 4 and 6 days, respectively. Result: Exhibited anti-tumor effect.
References	[1]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. [2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. [3]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206.