SB-216641A
Modify Date: 2025-08-25 16:35:24
SB-216641A structure
|
Common Name | SB-216641A | ||
|---|---|---|---|---|
| CAS Number | 193611-67-5 | Molecular Weight | 523.02300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H31ClN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SB-216641ASB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A blocks SKF-99101H from functioning in vivo[1][2]. |
| Name | N-{3-[2-(Dimethylamino)ethoxy]-4-methoxyphenyl}-2'-methyl-4'-(5-m ethyl-1,2,4-oxadiazol-3-yl)-4-biphenylcarboxamide hydrochloride ( 1:1) |
|---|
| Description | SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A blocks SKF-99101H from functioning in vivo[1][2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT1B Receptor 5-HT1D Receptor |
| In Vivo | SB-216641A (0.6–20 mg/kg；腹腔注射；单剂量) 在豚鼠内以剂量依赖性方式阻碍 SKF-99101H 诱导的低体温[1]。 SB-216641A (559 nmol/kg；静脉注射；单剂量) 与 5-HT1B/D 受体拮抗剂 GR-127935 联用时改善了狗注射 800 nmol/kg 舒马曲坦 Sumatriptan (HY-B0121B) 后观察到的胃松弛[2]。 Animal Model: Guinea pigs[1]. Dosage: 0.6, 2.0, 6.0 and 20.0 mg/kg. Administration: Intraperitoneal injection; single dose. Result: Significantly blocked the effects of SKF-99101H. Animal Model: Dogs[2]. Dosage: 559 nmol/kg. Administration: Intravenous injection; single dose. Result: Improved the gastric relaxation. |
| References |
| Molecular Formula | C28H31ClN4O4 |
|---|---|
| Molecular Weight | 523.02300 |
| Exact Mass | 522.20300 |
| PSA | 89.72000 |
| LogP | 6.09670 |
| InChIKey | JPBMDMNORXKGHZ-UHFFFAOYSA-N |
| SMILES | COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1OCCN(C)C.Cl |