LY3295668 (AK-01)

Modify Date: 2024-01-11 13:42:02

LY3295668 (AK-01) structure	Common Name	LY3295668 (AK-01)
	CAS Number	1919888-06-4	Molecular Weight	489.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₆ClF₂N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LY3295668 (AK-01)

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

Name	LY3295668

Description	LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer
Target	Aurora A:0.8 nM (IC50)
In Vitro	LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].
References	[1]. Gong X, et al. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469.

Molecular Formula	C₂₄H₂₆ClF₂N₅O₂
Molecular Weight	489.95
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: LY3295668 (AK-01)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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