Tenacissoside H

Modify Date: 2025-08-20 09:15:56

Tenacissoside H structure	Common Name	Tenacissoside H
	CAS Number	191729-45-0	Molecular Weight	794.965
	Density	1.3±0.1 g/cm3	Boiling Point	815.4±65.0 °C at 760 mmHg
	Molecular Formula	C₄₂H₆₆O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	235.5±27.8 °C

Use of Tenacissoside H

Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1]

Name	12-acetoxy-1-acetyl-8-((5-((3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10a,12a-dimethyltetradecahydro-1H-cyclopenta[1,2]phenanthro[1,10a-b]oxiren-11-yl 2-methylbutanoate
Synonym	More Synonyms

Description	Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1]
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Steroids Research Areas >> Cancer
References	[1]. Jia YS, et al. Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade. Evid Based Complement Alternat Med. 2015;2015:464937.

Density	1.3±0.1 g/cm3
Boiling Point	815.4±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₆₆O₁₄
Molecular Weight	794.965
Flash Point	235.5±27.8 °C
Exact Mass	794.445251
PSA	178.04000
LogP	4.73
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.551
InChIKey	HRSFCYYMBMDMOU-ZIAOJATMSA-N
SMILES	CCC(C)C(=O)OC1C2C3(C)CCC(OC4CC(OC)C(OC5OC(C)C(O)C(OC)C5O)C(C)O4)CC3CCC23OC32CCC(C(C)=O)C2(C)C1OC(C)=O

Safety Phrases	24/25
HS Code	29389090

(3β,5α,11α,12β,14β,17α)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl 2-meth ylbutanoate

Butanoic acid, 2-methyl-, (3β,5α,11α,12β,14β,17α)-12-(acetyloxy)-3-[[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy]-8,14-ep oxy-20-oxopregnan-11-yl ester

Tenacissoside H