J-104871
Modify Date: 2024-10-08 19:20:31
J-104871 structure
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Common Name | J-104871 | ||
|---|---|---|---|---|
| CAS Number | 191088-19-4 | Molecular Weight | 708.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H32N2O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of J-104871J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells. |
| Name | J-104871 |
|---|
| Description | J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells. |
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| References | 1. Yonemoto M, Satoh T, Arakawa H, Suzuki-Takahashi I, Monden Y, Kodera T, Tanaka K, Aoyama T, Iwasawa Y, Kamei T, Nishimura S, Tomimoto K. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54(1):1-7. PubMed PMID: 9658183. |
| Molecular Formula | C38H32N2O12 |
|---|---|
| Molecular Weight | 708.67 |
| InChIKey | CXDSZFRIMJUZKT-MRGWGSTCSA-N |
| SMILES | CC(C(CC=Cc1nc2ccccc2o1)c1ccc2c(c1)OCO2)N(Cc1ccc2ccccc2c1)C(=O)C1OC(C(=O)O)(C(=O)O)OC1C(=O)O |