191088-19-4
191088-19-4 structure
- Name: J-104871
- Chemical Name: J-104871
- CAS Number: 191088-19-4
- Molecular Formula: C38H32N2O12
- Molecular Weight: 708.67
- Create Date: 2024-10-08 19:20:31
- Modify Date: 2024-10-08 19:20:31
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J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
| Name | J-104871 |
|---|
| Description | J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells. |
|---|---|
| References | 1. Yonemoto M, Satoh T, Arakawa H, Suzuki-Takahashi I, Monden Y, Kodera T, Tanaka K, Aoyama T, Iwasawa Y, Kamei T, Nishimura S, Tomimoto K. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54(1):1-7. PubMed PMID: 9658183. |
| Molecular Formula | C38H32N2O12 |
|---|---|
| Molecular Weight | 708.67 |