PF 06260933 dihydrochloride
Modify Date: 2025-10-28 18:07:18
PF 06260933 dihydrochloride structure
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Common Name | PF 06260933 dihydrochloride | ||
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| CAS Number | 1883548-86-4 | Molecular Weight | 369.676 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H15Cl3N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF 06260933 dihydrochloridePF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice. |
| Name | 5-(4-Chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride |
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| Synonym | More Synonyms |
| Description | PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice. |
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| References | References 1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. 2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995. View Related Products by Target MAP4K |
| Molecular Formula | C16H15Cl3N4 |
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| Molecular Weight | 369.676 |
| Exact Mass | 368.036224 |
| InChIKey | VRQXEOPUAQLBQI-UHFFFAOYSA-N |
| SMILES | Cl.Cl.Nc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1 |
| 5-(4-Chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride |
| [3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-, hydrochloride (1:2) |