PF 06260933 dihydrochloride

Names

[ Name ]:
PF 06260933 dihydrochloride

[Synonym ]:
5-(4-Chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride
[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-, hydrochloride (1:2)

Biological Activity

[Description]:

PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.

[References]

References 1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. 2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995. View Related Products by Target MAP4K

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₅Cl₃N₄

[ Molecular Weight ]:
369.676

[ Exact Mass ]:
368.036224

Related Compounds

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