Rimeporide hydrochloride

Modify Date: 2024-01-28 12:05:40

Rimeporide hydrochloride structure	Common Name	Rimeporide hydrochloride
	CAS Number	187870-95-7	Molecular Weight	369.84500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₆ClN₃O₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Rimeporide hydrochloride

Rimeporide hydrochloride is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

Name	n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid
Synonym	More Synonyms

Description	Rimeporide hydrochloride is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease
Target	NHE1[1]
In Vitro	Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].
References	[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.

Molecular Formula	C₁₁H₁₆ClN₃O₅S₂
Molecular Weight	369.84500
Exact Mass	369.02200
PSA	164.01000
LogP	3.57980

Rimeporide Hydrochloride