187870-95-7

187870-95-7 structure

Name: Rimeporide hydrochloride
Chemical Name: n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid
CAS Number: 187870-95-7
Molecular Formula: C₁₁H₁₆ClN₃O₅S₂
Molecular Weight: 369.84500
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2016-05-12 08:06:52
Modify Date: 2024-01-28 12:05:40
Rimeporide hydrochloride is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

Name	n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid
Synonyms	Rimeporide Hydrochloride

Description	Rimeporide hydrochloride is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease
Target	NHE1[1]
In Vitro	Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].
References	[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.