Rimeporide hydrochloride

Names

[ CAS No. ]:
187870-95-7

[ Name ]:
Rimeporide hydrochloride

[Synonym ]:
Rimeporide Hydrochloride

Biological Activity

[Description]:

Rimeporide hydrochloride is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Metabolic Disease

[Target]

NHE1[1]

[In Vitro]

Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].

[References]

[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₆ClN₃O₅S₂

[ Molecular Weight ]:
369.84500

[ Exact Mass ]:
369.02200

[ PSA ]:
164.01000

[ LogP ]:
3.57980

Related Compounds

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